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Guo Lei, orcid.org/0009-0006-4877-5288 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Many P450 enzymes are subject to genetic polymorphism in which some people are endowed with robust metabolic activity (so-called rapid metabolizers) and others have none at all

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These results suggest that S-PLGA transdermal films provide a promising, non-invasive, and sustained delivery system for treating PD 128